The downloadable materials included on this website are provided to interested parties at no cost; however, to download any material you need to register by completing a form with your name, e-mail address and affiliation. The registration information provides us with contact information so that we can send notifications for model updates. The models are updated occasionally to address potential errors and “bugs in the code” and to reflect scientific advancements.
The most recent versions of the models and databases are most relevant since they include updates and possibly corrections to previous versions. Users are strongly encouraged to read the associated papers listed with the models and the “help” and “about” information accompanying the models (when included) before using them. Excel spreadsheets are expected to work using Microsoft Office or other similar programs (Note: Visual Basic for Applications support is often required).
For more information about these models, tools and databases please contact Jon Arnot.
Risk Assessment IDentification And Ranking (RAIDAR) Model
Risk Assessment IDentification And Ranking – Indoor and Consumer Exposure (RAIDAR-ICE) Model
The Indoor Chemical Exposure Classification/Ranking Model (ICECRM)
FHX (Far-field Human eXposure) model
FHX-CAN (Far-field Human eXposure in Canada) model
In Vitro Mass Balance Model (IV-MBM)
AQUAWEB (Aquatic Food Web) model
Bioconcentration for Ionizable Organics (BIONIC)
San Francisco Bay Food Web Bioaccumulation model
Screening-level BCF and BAF models
Human Biotransformation and Total Elimination Half-life QSARs (IFS)
Fish biotransformation rate constant (or half-life) QSARs
The OECD has developed standardized test guidelines for measuring in vitro biotransformation rates using S9 and hepatocyte (HEP) assay systems from rainbow trout liver tissues. Models are required to extrapolate the in vitro rates to in vivo liver clearance and whole body biotransformation rates and to incorporate these rates in toxicokinetic models to calculate bioaccumulation assessment endpoints such as the bioconcentration factor (BCF). One model for extrapolating in vitro S9 and HEP biotransformation rates to fish BCFs is the one developed by Nichols et al. 2013. An on-line version of the Nichols et al., 2013 IVIVE-Fish BCF model is available.
Limitations of liability and disclaimer of warranty
Users assume the entire risk as to the results and performance of the models and databases. ARC Arnot Research & Consulting Inc. and all associated collaborators are not liable under any circumstances, for any damages whatsoever, arising out of the use, or the inability to use, the models and databases provided, even if advised of the possibility of such damages.