MODELS & TOOLS
The downloadable materials included on this website are provided to interested parties at no cost; however, to download any material you need to first request a password by completing a form with your name, e-mail address and affiliation. The registration information provides us with contact information so that we can send notifications for model updates. The models are updated occasionally to address potential errors and “bugs in the code” and to reflect scientific advancements.
The most recent versions of the models and databases are most relevant since they include updates and possibly corrections to previous versions. Users are strongly encouraged to read the associated papers listed with the models and the “help” and “about” information accompanying the models (when included) before using them. Excel spreadsheets are expected to work using Microsoft Office or other similar programs (Note: Visual Basic for Applications support is often required).
For more information about these models, tools and databases please contact Jon Arnot.
The Bioaccumulation Assessment Tool (BAT)
The Bioaccumulation Assessment Tool (BAT) facilitates the systematic and transparent integration of information in a consistent framework to inform bioaccumulation assessment decision-making.
The BAT is a user-friendly spreadsheet-based tool to guide the collection, generation, evaluation, and integration of various lines of evidence (LOE) to aid bioaccumulation assessment decision-making for aquatic and terrestrial organisms. The BAT provides a consistent Quantitative Weight of Evidence (QWOE) approach that includes critical evaluations of data confidence. The BAT can provide guidance for integrated testing strategies should further information be necessary for decision-making.
Chemicals are being assessed for bioaccumulation (B) potential using various LOEs, methods, metrics and classification criteria. In vivo laboratory-based lines of evidence include the bioconcentration factor (BCF) and biomagnification factor (BMF). In vitro biotransformation rate data (S9, hepatocytes) can also be applied for “B” assessment using in vitro-in vivo extrapolation (IVIVE) methods. Field-based LOEs include the BMF, bioaccumulation factor (BAF), and the Trophic Magnification Factor (TMF). In silico LOEs include quantitative structure-activity relationships (QSARs) for the BCF and the biotransformation rate constant (kB) and mass balance bioaccumulation (toxicokinetic) models.
The BAT was developed with stakeholder involvement including representatives from academia, government and industry with research support from Cefic-LRI. The BAT is implemented (coded) in Visual Basic for Applications (VBA) and the Graphical User Interface is designed in Excel™. The BAT User Manual and Quick Start Guide are embedded as pdfs within the Excel file. This Quick Start Guide can be considered to expedite the use of the BAT; however, all BAT users are strongly encouraged to read the User Manual before using the BAT. A recent presentation of the BAT system given to stakeholders is available here.
How to Cite:
– Armitage JM, Toose L, Embry M, Foster KL, Hughes L, Arnot JA. 2018. The Bioaccumulation Assessment Tool (BAT) Version 1.0. Developed by ARC Arnot Research and Consulting Inc., Toronto, ON, Canada
BAT Ver.1.0 was publicly released October 2018.
BAT Ver.1.01 released September 2019
* Please carefully follow all instructions on the download request form
Risk Assessment IDentification and Ranking (RAIDAR) Model
Risk Assessment IDentification and Ranking – Indoor and Consumer Exposure (RAIDAR-ICE) Model
The Indoor Chemical Exposure Classification/Ranking Model (ICECRM)
FHX (Far-field Human eXposure) model
FHX-CAN (Far-field Human eXposure in Canada) model
In Vitro Mass Balance Model (IV-MBM)
AQUAWEB (Aquatic Food Web) model
Bioconcentration for Ionizable Organics (BIONIC)
San Francisco Bay Food Web Bioaccumulation model
Screening-level BCF and BAF models
Human Biotransformation and Total Elimination Half-life QSARs (IFS)
Fish biotransformation rate constant (or half-life) QSARs
The OECD has developed standardized test guidelines for measuring in vitro biotransformation rates using S9 and hepatocyte (HEP) assay systems from rainbow trout liver tissues. Models are required to extrapolate the in vitro rates to in vivo liver clearance and whole body biotransformation rates and to incorporate these rates in toxicokinetic models to calculate bioaccumulation assessment endpoints such as the bioconcentration factor (BCF). One model for extrapolating in vitro S9 and HEP biotransformation rates to fish BCFs is the one developed by Nichols et al. 2013. An on-line version of the Nichols et al., 2013 IVIVE-Fish BCF model is available.
Limitations of liability and disclaimer of warranty
Users assume the entire risk as to the results and performance of the models and databases. ARC Arnot Research & Consulting Inc. and all associated collaborators are not liable under any circumstances, for any damages whatsoever, arising out of the use, or the inability to use, the models and databases provided, even if advised of the possibility of such damages.