Brown TN, Armitage JM, Sangion A, Arnot JA. 2024. Improved prediction of PFAS partitioning with PPLFERs and QSPRs. Environ Sci: Processes Impacts Accepted DOI

Brown TN, Sangion A, Arnot JA. 2024. Identifying uncertainty in physical–chemical property estimation with IFSQSAR. J Cheminf, 16:65. DOI

Zhang Z, Wang S, Brown TN, Sangion A, Arnot JA, Li L. 2024. Modeling sorption of environmental organic chemicals from water to soils. Water Res X 22:100219. DOI

Zhang Z, Sangion A, Wang S, Gouin T, Brown T, Arnot JA, Li L. 2024. Chemical space covered by applicability domains of quantitative structure-property relationships and semiempirical relationships in chemical assessments. Environ Sci Technol58(7): 3386-3398 DOI

Zaleski RT, Ahrens A, Arnot JA, Becker RA, Bonnell M, Collins S, DeLeo P, Egeghy P, Embry M, Gouin T, Isaacs K, Jensen E. 2023. Quantitative structure use relationships: Highlights from a technical summit meeting. Regul Toxicol Pharmacol, 105516. DOI

Zhang Z, Sangion A, Wang S, Gouin T, Brown T, Arnot JA, Li L. 2023. Hazard vs. exposure: Does it make a difference in identifying chemicals with persistence and mobility concerns? Water Res, 120610. DOI

McLachlan MS, Ebert A, Armitage JM, Arnot JA, Droge STJ. 2023. A framework for understanding the bioconcentration of surfactants in fish. Environ Sci: Processes Impacts 25(7): 1238-1251 DOI

Saunders LJ, Nichols JW, Arnot JA, Armitage JM, Wania, F. 2023. An amended in vitro–in vivo extrapolation model that accounts for first pass clearance effects on chemical bioaccumulation in fish. Environ Sci: Processes Impacts 25(4): 741-754 DOI

Arnot JA, Toose L, Armitage JM, Embry M, Sangion A, Hughes L. 2023. A weight of evidence approach for bioaccumulation assessment. Integr Environ Assess Manag. 19(5): 1235-1253 DOI

Arnot JA, Toose L, Armitage JM, Sangion A, Looky A, Brown TN, Li L, Becker RA. 2022. Developing an internal threshold of toxicological concern (iTTC). J Expo Sci Environ Epidemiol 32: 877–884 DOI

Bischof I, Arnot JA, Jürling H, Knipschild G, Schlechtriem C, Schauerte A, Segner H. 2022. In vitro biotransformation assays using fish liver cells: Comparing rainbow trout and carp hepatocytes. Front Toxicol 4: 1021880 DOI

Zare Jeddi M, Hopf NB, Louro H, Viegas S, Galea KS, Pasanen-Kase R, Santonen T, Mustieles V, Fernandez MF, Verhagen H, Bopp SK, Philippe Antignac J, David A, Mol H, Barouki R, Audouze K, Duca R-C, Fantke P, Scheepers P, Ghosh M, Van Nieuwenhuyse A, Lobo Vicente J, Trier X, Rambaud L, Fillol C, Denys S, Conrad A, Kolossa-Gehring M, Paini A, Arnot, J, Schulze F, Jones K, Sepai O, Ali I, Brennan L, Benfenati E, Cubadda F, Mantovani A, Bartonova A, Connolly A, Slobodnik J, Bruinen de Bruin Y, van Klaveren J, Palmen N, Dirven H, Husøy T, Thomsen C, Virgolino A, Röösli M, Gant T, von Goetz N, Bessems J. 2022. Developing human biomonitoring as a 21^st Century toolbox within the European exposure science strategy 2022−2030. Environ Int 168:107476. DOI

Bloch S, Arnot JA, Kramer NI, Armitage JM, Verner M-A. 2022. Dynamic mass balance modeling for chemical distribution over time in in vitro systems with repeated dosing. Front Toxicol 4: 911128 DOI

Li L, Zhang Z, Men Y, Baskaran S, Sangion A, Wang S, Arnot JA, Wania F. 2022. Retrieval, selection, and evaluation of chemical property data for assessments of chemical emissions, fate, hazard, exposure, and risks. ACS Environmental Au 2(5): 376-395 DOI

Ribbenstedt A, Armitage JM, Günther F, Arnot JA, Droge STJ, McLachlan MS. 2022. In vivo bioconcentration of 10 anionic surfactants in rainbow trout explained by in vitro data on partitioning and S9 clearance. Environ Sci Technol 56(10): 6305-6314. DOI

Berthiaume A, Arnot JA, Toose L. 2022. Risk-based prioritization of organic substances in the Canadian National Pollutant Release Inventory using an evaluative regional-scale multimedia mass balance model. Integr Environ Assess Manag. 18(6):1722-1732  DOI

Li L, Sangion A, Wania F, Armitage JM, Toose L, Hughes L, Arnot JA. 2021. Development and evaluation of a holistic and mechanistic modeling framework for chemical emissions, fate, exposure, and risk. Environ Health Persp 129(12): 127006 DOI

Armitage JM, Sangion A, Parmar R, Looky A, Arnot JA. 2021. Update and evaluation of a high-throughput in vitro mass balance distribution model: IV-MBM EQP v2.0. Toxics Special Issue “Computational Toxicology: Expanding Frontiers in Risk Assessment” 9(11): 315 DOI

Droge STJ, Scherpenisse P, Arnot JA, Armitage JM, McLachlan MS, von der Ohe PC, Hodges G. 2021. Screening the baseline fish bioconcentration factor of various types of surfactants using phospholipid binding data. Environ Sci: Processes Impacts23(12): 1930-1948 DOI

Droge STJ, Armitage JM, Arnot JA, Fitzsimmons PN, Nichols JW. 2021. Biotransformation potential of cationic surfactants in fish assessed with Rainbow trout liver S9 fractions. Environ Toxicol Chem 40(11): 3123-3136. DOI

Kierkegaard A, Sundbom M, Yuan B, Armitage JM, Arnot JA, Droge STJ, McLachlan MS. 2021. Bioconcentration of several series of cationic surfactants in rainbow trout. Environ Sci Technol 55(13): 8888-8897. DOI

Armitage JM, Hughes L, Sangion A, Arnot JA. 2021. Development and intercomparison of single and multicompartment physiologically-based toxicokinetic models: Implications for model selection and tiered modeling frameworks. Environ Int154:106557. DOI

Gobas FAPC, Lee Y-S, Arnot JA. 2021. Normalizing the biomagnification factor. Environ Toxicol Chem 14(4): 1204-1211. DOI

Armitage JM, Toose L, Camenzuli L, Redman A, Parkerton TF, Saunders D, Wheeler J, Martin A, Arnot JA, Vaiopoulou E. 2021. A critical review and weight of evidence approach for assessing the bioaccumulation of phenanthrene in aquatic environments. Integr Environ Assess Manag. 17(5): 911-925. DOI

Li L, Hughes L, Arnot JA. 2021. Addressing uncertainty in mouthing-mediated ingestion of chemicals on indoor surfaces, objects, and dust. Environ Int 146: 106266. DOI

Laue H, Hostettler L, Badertscher RP, Jenner KJ, Sanders G, Arnot JA, Natsch A. 2020. Examining uncertainty in in vitro–in vivo extrapolation applied in fish bioconcentration models. Environ Sci Technol 54(15): 9483–9494. DOI

Kierkegaard A, Chen CE, Armitage JM, Arnot JA, Droge STJ, McLachlan MS. 2020. Tissue distribution of several series of cationic surfactants in rainbow trout (Oncorhynchus mykiss) following exposure via water. Environ Sci Technol 54(7): 4190-4199. DOI

Mackay D, Celsie AKD, Parnis JM, Arnot JA. 2020. A perspective on the role of fugacity and activity for evaluating the PBT properties of organic chemicals and providing a multi-media synoptic indicator of environmental contamination. Environ Sci: Processes Impacts 22: 518-527. DOI

Li L, Hoang C, Arnot JA, Wania F. 2020. Clarifying temporal trend variability in human biomonitoring of polybrominated diphenyl ethers through mechanistic modeling. Environ Sci Technol 54(1): 166-175. DOI

Aylward L, Vilone G, Cowan-Ellsberry C, Arnot JA, Westgate JN, O’Mahony C, Hays SM. 2020. Exposure to selected preservatives in personal care products:  Case study comparison of exposure models and observational biomonitoring data. J Expo Sci Environ Epidemiol 30(1): 28-41. DOI

Li L, Arnot JA, Wania F. 2019. How are humans exposed to organic chemicals released to indoor air? Environ Sci Technol 53(19): 11276-11284. DOI

Brown TN, Armitage JM, Arnot JA. 2019. Application of an iterative fragment selection (IFS) method to estimate entropies of fusion and melting points of organic chemicals. Mol Inform 38(8-9). DOI

Quinn C, Armitage JM, Wania F, Arnot JA. 2019. Development and evaluation of a combined bioenergetics and organic chemical mass-balance bioaccumulation model for fish. Environ Sci Technol 53(2): 752-759. DOI

Ring CL, Arnot JA, Bennett DH, Egeghy PP, Fantke P, Huang L, Isaacs KK, Jolliet O, Phillips KA, Price PS, Shin, H-M, Westgate JN, Setzer RW, Wambaugh JF. 2019. Consensus modeling of median chemical intake based on predictions of exposure pathways. Environ Sci Technol 53(2): 719-732. DOI

Nguyen VK, Colacino JA, Arnot JA, Kvasnicka J, Jolliet O. 2019. Characterization of age-based trends to identify chemical biomarkers of higher levels in children. Environ Int 122: 117-129. DOI

Li L, Westgate JN, Hughes L, Zhang X, Givehchi B, Toose L, Armitage JM, Wania F, Egeghy P, Arnot JA. 2018. A model for risk-based screening and prioritization of near-field human exposure to chemicals. Environ Sci Technol 52(24): 14235-14244. DOI

Schmidt SN, Armitage JM, Arnot JA, Mackay D, Mayer P. 2018. Linking algal growth inhibition to chemical activity: Excess toxicity below 0.1% of saturation. Chemosphere 208: 880-886. DOI

Li L, Arnot JA, Wania F. 2018. Towards a systematic understanding of the dynamic fate of polychlorinated biphenyls in indoor, urban and rural environments. Environ Int 117: 57-68. DOI

Li L, Arnot JA, Wania F. 2018. Revisiting the contributions of far- and near-field routes to aggregate human exposure to polychlorinated biphenyls (PCBs). Environ Sci Technol 52(12): 6974-6984. DOI

Arnot JA, Pawlowski S, Champ S. 2018. A weight-of-evidence approach for the bioaccumulation assessment of triclosan in aquatic species. Sci. Total Environ. 618: 1506-1518. DOI

Papa E, Sangion A, Arnot JA, Gramatica P. 2018. Development of human biotransformation QSARs and application for PBT assessment refinement. Food Chem Toxicol 112: 535-543. DOI

Arnot JA, Mackay D. 2018. The influence of chemical degradation during dietary exposures to fish on biomagnification factors and bioaccumulation factors. Environ Sci: Processes Impacts 20(1): 86 - 97. DOI

Doucette WJ, Shunthirasingham C, Dettenmaier EM, Zaleski RT, Fantke P, Arnot JA. 2018. A review of measured bioaccumulation data in terrestrial plants for organic chemicals: metrics, variability and the need for standardized measurement protocols. Environ Toxicol Chem 37(1): 21-33. DOI

Mackay D, Celsie AKD, Parnis JM, McCarty LSM, Arnot JA, Powell DE. 2017. The chemical exposure toxicity space (CETS) model:  Relating exposure, concentration, activity, and toxicity onset time. Environ Toxicol Chem 36(5): 1389–1396. DOI

Armitage JM, Erickson RJ, Luckenbach T, Ng CA, Prosser RS, Arnot JA, Schirmer K, Nichols JW. 2017. Assessing the bioaccumulation potential of ionizable organic compounds: Current knowledge and research priorities. Environ Toxicol Chem 36(4): 882-897. DOI

Chen Y, Hermens JLM, Jonker MTO, Arnot JA, Armitage JM, Brown TN, Nichols JW, Fay KA, Droge STJ. 2016. Which molecular features affect the intrinsic hepatic clearance rate of ionized ionizable organic chemicals in fish? Environ Sci Technol 50(23): 12722-12731. DOI

Fantke P, Arnot JA, Doucette W. 2016. Improving plant bioaccumulation science through consistent reporting of experimental data. J Environ Manage. 181: 374-384. DOI

Brown TN, Armitage JM, Egeghy PP, Kircanski I, Arnot JA. 2016. Dermal permeation data and models for the prioritization and screening-level exposure assessment of organic chemicals. Environ Int 94: 424-435. DOI

Binnington MJ, Curren MS, Quinn CL, Armitage JM, Arnot JA, Chan HM, Wania, F. 2016. Mechanistic polychlorinated biphenyl exposure modeling of mothers in the Canadian Arctic: the challenge of reliably establishing dietary composition. Environ Int 92–93: 256-268. DOI

Mackay D, Celsie AKD, Arnot JA, Powell DE. 2016. Processes influencing chemical biomagnification and trophic magnification factors in aquatic ecosystems: Implications for chemical hazard and risk assessment. Chemosphere 154: 99-108. DOI

Thomas P, Mackay D, Mayer P, Arnot J, Galay Burgos M. 2016. Response to Comment on “Application of the Activity Framework for Assessing Aquatic Ecotoxicology Data for Organic Chemicals”. Environ Sci Technol 50(7): 4141-4142. DOI

Kim J, Gobas FAPC, Arnot JA, Powell DE, Seston RM, Woodburn KB. 2016. Evaluating the roles of biotransformation, spatial concentration differences, organism home range, and field sampling design on trophic magnification factors. Sci Total Environ 551-552: 438-451. DOI

Celsie A, Mackay D, Parnis JM, Arnot JA. 2016. A fugacity-based toxicokinetic model for narcotic organic chemicals in fish. Environ Toxicol Chem 35(5): 1257-1267. DOI

Gobas FAPC, Burkhard L, Doucette W, Sappington K, Verbruggen E, Hope B, Bonnell M, Arnot JA, Tarazona J. 2016. Review of existing terrestrial bioaccumulation models and terrestrial bioaccumulation modeling needs for organic chemicals. Integr Environ Assess Manag 12(11): 123-134. DOI

Xiao R, Arnot JA, MacLeod M. 2015. Towards an improved understanding of processes controlling absorption efficiency and biomagnification of organic chemicals by fish. Chemosphere 138: 89–95. DOI

Thomas PC, Dawick J, Lampi MA, Lemaire P, Presow S, van Egmond R, Arnot JA, Mackay D, Mayer P, Galay Burgos M. 2015. Application of the activity framework for assessing aquatic ecotoxicology data for organic chemicals. Environ Sci Technol 49(20): 12289-12296. DOI

Shin H-M, Ernstoff A, Arnot JA, Wetmore B, Csiszar S, Fantke P, Zhang X, McKone T, Jolliet O, Bennett D. 2015. Risk-based high-throughput chemical screening and prioritization using exposure models and in vitro bioactivity assays. Environ Sci Technol 49(11): 6760-71. DOI

Arnot JA, Quinn CL. 2015. Development and evaluation of a database of dietary bioaccumulation test data for organic chemicals in fish. Environ Sci Technol 49(8): 4783-4796. DOI

McLeod AM, Arnot JA, Borgå K, Selck H, Kashian D, Krause A, Paterson G, Haffner GD, Drouillard KG. 2015. Quantifying uncertainty in the trophic magnification factor related to spatial movements of organisms in a food web. Integr Environ Assess Manag 11(2): 306-318. DOI

Zhang X, Arnot JA, Wania F. 2014. Model for screening-level assessment of near-field human exposure to neutral organic chemicals released indoors. Environ Sci Technol 48(20): 12312–12319. DOI

Armitage JM, Wania F, Arnot JA. 2014. Application of mass balance models and the chemical activity concept to facilitate the use of in vitro toxicity data for risk assessment. Environ Sci Technol 48(16): 9770-9779. DOI

Mackay D, McCarty LS, Arnot JA. 2014. Relationships between exposure and dose in aquatic toxicity tests for organic chemicals. Environ Toxicol Chem 33(9): 2038-2046. DOI

McLachlan MS, Kierkegaard A, Radke M, Sobek A, Malmvärn A, Alsberg T, Arnot JA, Brown TN, Wania F, Breivik K, Xu S. 2014. Using model-based screening to help discover unknown environmental contaminants. Environ Sci Technol 48(13): 7264-7271. DOI

Mackay D, Arnot JA, Celsie A, Orazietti A, Parnis JM. 2014. QSARs for aquatic toxicity: Celebrating, extending and displaying the pioneering contributions of Ferguson, Konemann and Veith. SAR QSAR Environ Res 25(5):343-55. DOI

Arnot JA, Brown TN, Wania F. 2014. Estimating screening-level organic chemical half-lives in humans. Environ Sci Technol 48(1): 723–730. DOI

Papa E, van der Wal L, Arnot JA, Gramatica P. 2014. Metabolic biotransformation half-lives in fish: QSAR modelling and consensus analysis. Sci Total Environ 470–471: 1040–1046. DOI

Krogseth IS, Breivik K, Arnot JA, Wania F, Borgen AR, Schlabach M. 2013. Evaluating the environmental fate of short-chain chlorinated paraffins (SCCPs) in the Nordic environment using a dynamic multimedia model. Environ Sci: Processes Impacts12(15): 2240-2251. DOI

McCarty LS, Arnot JA, Mackay D. 2013. Evaluation of critical body residue data for acute narcosis in aquatic organisms. Environ Toxicol Chem 32(10): 2301-14. DOI

Wambaugh JF, Setzer RW, Reif DM, Gangwal S, Mitchell-Blackwood J, Arnot JA, Joliet O, Frame A, Rabinowitz J, Knudsen TB, Judson RS, Egeghy P, Vallero D, Cohen Hubal EA. 2013. High-throughput models for exposure-based chemical prioritization in the ExpoCast project. Environ Sci Technol 47 (15): 8479–8488. DOI

Mitchell J, Arnot JA, Jolliet O, Georgopoulos PG, Isukapalli S, Dasgupta S, Pandian M, Wambaugh J, Egeghy P, Cohen Hubal EA, Vallero DA. 2013. Comparison of modeling approaches to prioritize chemicals based on estimates of exposure and exposure potential. Sci Total Environ, 458–460: 555-567. DOI

Mackay D, Arnot JA, Gobas FAPC, Powell D. 2013. Mathematical relationships between metrics of bioaccumulation. Environ Toxicol Chem 32(7): 1459-1466. DOI

Nichols JW, Huggett DB, Arnot JA, Fitzsimmons PN, Cowan-Ellsberry CE. 2013. Towards improved models for predicting bioconcentration of well-metabolized compounds by rainbow trout using measured rates of in vitro intrinsic clearance. Environ Toxicol Chem 32(7): 1611-1622. DOI

Armitage JM, Arnot JA, Wania F, Mackay D. 2013. Development and evaluation of a mechanistic bioconcentration model for ionogenic organic chemicals in fish. Environ Toxicol Chem 32(1): 115-128. DOI

Armitage JM, Arnot JA, Wania F. 2012. Potential role of phospholipids in determining the internal tissue distribution of perfluoroalkyl acids in biota. Environ Sci Technol 46(22): 12285−12286. DOI

Arnot JA, Brown TN, Wania F, Breivik K, McLachlan MS. 2012. Prioritizing chemicals and data requirements for screening-level exposure and risk assessment. Environ Health Persp 120(11): 1565-1570. DOI

Costanza J, Boethling RS, Lynch DG, Arnot JA. 2012. Use of the bioaccumulation factor to screen chemicals for bioaccumulation potential. Environ Toxicol Chem 31(10): 2261-2268. DOI

Brown TN, Arnot JA, Wania F. 2012. Iterative fragment selection: A group contribution approach to predicting fish biotransformation half-lives. Environ Sci Technol 46(15): 8253-8260. DOI

Breivik K, Arnot JA, Brown TN, McLachlan MS, Wania F. 2012. Screening organic chemicals in commerce for emissions in the context of environmental and human exposure. J Environ Monit 14: 2028-2037. DOI

Gama SR, Mackay D, Arnot JA. 2012. Selecting and designing chemicals: application of a mass balance model of chemical fate, exposure and effects in the environment. Green Chem 14:1094-1102. DOI

Burkhard L, Arnot JA, Embry M, Farley K, Hoke R, Kitano M, Leslie HA, Lotufo GR, Parkerton TF, Sappington KG, Tomy GT, Woodburn K. 2012. Comparing laboratory and field measured biota-sediment accumulation factors. Integr Environ Assess Manag 8(1): 32-41. DOI

Burkhard L, Arnot JA, Embry M, Farley K, Hoke R, Kitano M, Leslie HA, Lotufo GR, Parkerton TF, Sappington KG, Tomy GT, Woodburn K. 2012. Comparing laboratory and field measured bioaccumulation endpoints. Integr Environ Assess Manag 8(1): 17-31. DOI

Marvin CH, Tomy GT, Armitage JM, Arnot JA, McCarty LS, Covaci A, Palace V. 2011. Hexabromocyclododecane: current understanding of chemistry, environmental fate and toxicology and implications for global management. Environ Sci Technol45(20): 8613-8623. DOI

Sverko E, Tomy GT, Reiner EJ, Li Y-F, McCarry BE, Arnot JA, Law RJ, Hites RA. 2011. Dechlorane Plus and related compounds in the environment: a review. Environ Sci Technol 45(12): 5088-5098. DOI

Mackay D, Arnot JA. 2011. The application of fugacity and activity to simulating the environmental fate of organic contaminants. J Chem Eng Data 56(4): 1348-1355. DOI

Mackay D, Arnot JA, Wania F, Bailey RE. 2011. Chemical activity as an integrating concept in environmental assessment and management of contaminants. Integr Environ Assess Manag 7(2): 248-255. DOI

Arnot JA, Armitage JM, McCarty LS, Wania F, Cousins I, Toose-Reid L. 2011. Toward a consistent evaluative framework for POP risk characterization. Environ Sci Technol 45(1): 97-103 Special Issue on Environmental Policy: Past, Present and Future– Invited. DOI

McLachlan MS, Czub G, MacLeod M, Arnot JA. 2011. Bioaccumulation of organic contaminants in humans: A multimedia perspective and the importance of biotransformation. Environ Sci Technol 45(1): 197-202 Special Issue on Environmental Policy: Past, Present and Future DOI

Arnot JA, Mackay D, Sutcliffe R, Lo B. 2010. Estimating farfield organic chemical exposures, intake rates and intake fractions to human age classes. Environ Modell Softw 25:1166-1175. DOI

Gobas FAPC, Arnot JA. 2010. Food web bioaccumulation model for polychlorinated biphenyls in San Francisco Bay, California, USA. Environ Toxicol Chem 29:1385-1395. DOI

Arnot JA, Arnot MI, Mackay D, Couillard Y, MacDonald D, Bonnell M, Doyle P. 2010. Molecular size cut-off criteria for assessing bioaccumulation potential: Fact or fiction? Integr Environ Assess Manag 6(2): 210-224. DOI

Arnot JA, Mackay D, Parkerton TF, Zaleski RT, Warren CS. 2010. Multimedia modelling of human exposure to chemical substances: the roles of biomagnification and biotransformation. Environ Toxicol Chem 29(1): 45-55. DOI

Cowan-Ellsberry C, McLachlan M, Arnot JA, MacLeod MJ, McKone TE, Wania F. 2009. Modeling exposure to persistent chemicals in hazard and risk assessment. Integr Environ Assess Manag 5(4): 662-679. DOI

Mackay D, Arnot JA, Petkova EP, Wallace KB, Call DJ, Brooke LT, Veith GD. 2009. The physicochemical basis of QSARs for baseline toxicity. SAR and QSAR in Environmental Research 20: 393-414. DOI

Warren CS, Mackay D, Webster E, Arnot JA. 2009. A cautionary note on implications of the well-mixed compartment assumption as applied to mass balance models of chemical fate in flowing systems. Environ Toxicol Chem 28(9): 1858-1865. DOI

Arnot JA, Meylan W, Tunkel J, Howard PH, Mackay D, Bonnell M, Boethling RS. 2009. A quantitative structure-activity relationship for predicting metabolic biotransformation rates for organic chemicals in fish. Environ Toxicol Chem 28(6): 1168-1177 SETAC Best Student Paper Award DOI

Powell A, Mackay D, Webster E, Arnot JA. 2009. Modelling bioaccumulation using characteristic times. Environ Toxicol Chem28(2): 272-278. DOI

Arnot JA, Mackay D, Parkerton TF, Bonnell M. 2008. A database of fish biotransformation rates for organic chemicals. Environ Toxicol Chem 27(11): 2263-2270. DOI

Arnot JA, Mackay D. 2008. Policies for chemical hazard and risk priority setting: can persistence, bioaccumulation, toxicity and quantity information be combined? Environ Sci Technol 42: 4648-4654 DOI

Arnot JA, Mackay D, Bonnell M. 2008. Estimating metabolic biotransformation rates in fish from laboratory data. Environ Toxicol Chem 27(2): 341-351. DOI

Parkerton TF, Arnot JA, Weisbrod AV, Russom C, Hoke RA, Woodburn K, Traas T, Bonnell M, Burkhard LP and Lampi, MA. 2008. Guidance for evaluating in-vivo fish bioaccumulation data. Integr Environ Assess Manag 4(2): 139-155. DOI

Weisbrod AV, Burkhard LP, Arnot JA, Mekenyan O, Howard PH, Russom C, Boethling R, Sakuratani Y, Traas T, Bridges T, Lutz C, Bonnell M, Woodburn K. 2007. Workgroup report: review of fish bioaccumulation databases used to identify persistent, bioaccumulative, toxic substances. Environ Health Persp 115(2): 255-261. DOI

Arnot JA, Mackay D, Webster E, Southwood J. 2006. Screening level risk assessment model for chemical fate and effects in the environment. Environ Sci Technol 40: 2316-2323. DOI

Arnot JA, Gobas FAPC. 2006. A review of bioconcentration factor (BCF) and bioaccumulation factor (BAF) assessments for organic chemicals in aquatic organisms. Environ Rev 14: 257-297. DOI

Arnot JA, Gobas FAPC. 2004. A food web bioaccumulation model for organic chemicals in aquatic ecosystems. Environ Toxicol Chem 23(10): 2343–2355. DOI

Arnot JA, Gobas FAPC. 2003. A generic QSAR for assessing the bioaccumulation potential of organic chemicals in aquatic food webs. QSAR Comb Sci 22(3): 337-345. DOI

Gobas FAPC, Kelly BC, Arnot JA. 2003. Quantitative structure-activity relationships for predicting the bioaccumulation of POPs in terrestrial food webs. QSAR Comb Sci 22(3): 329-336. DOI

Arnot J, Toose L, Sangion A. 2024. Improving organic chemical assessment capacity within the Government of Canada using EAS-E Suite. Technical Report prepared for Health Canada.

Sangion A, Toose L, Li L, Arnot J. 2024. Functionality Updates to EAS-E Suite Modules: CiP-CAFE and RAIDAR. Technical Report for Environment and Climate Change Canada.

Armitage J, Sangion A, Arnot J. 2024. Data and tools to aid the experimental design for cannabinoids and related organic chemicals for in vitro testing. Technical Report prepared for Health Canada.

Arnot J, Brown T, Toose L, Armitage J, Sangion A. 2024. Scoping the uncertainty in screening for bioaccumulation potential of substances including an assessment of alternative surrogates and toxicokinetic methods. Technical Report prepared for Chemical Assessment Unit, United Kingdom Environment Agency.

Arnot J, Brown TN, Li L, Sangion A. 2023. Improving chemical use and emission rate information to address uncertainty in chemical safety assessments. Next steps to incorporate higher tiered use data into EAS-E Suite and status of PV and use databases in EAS-E Suite. Technical Report prepared for American Chemistry Council Long-Range Research Initiative (ACC-LRI).

Sangion A, Armitage J, Arnot J. 2023. Addressing uncertainty in toxicokinetics data and applications to advance chemical exposure and risk assessment. Phase 2 – Theme 1: Analysis of toxicokinetic data. Technical Report prepared for ExxonMobil Biomedical Sciences.

Armitage J, Sangion A, Arnot J. 2023. Developing a confidence framework to characterize uncertainty in the application of NAMs in a risk assessment context. Technical Report prepared for Health Canada.

Armitage J, Sangion A, Arnot J. 2023. Advancing high-throughput toxicokinetics, exposure models and new approach methods (NAMs) for risk assessment activities. Technical Report prepared for Health Canada.

Sangion A, Brown TN, Toose L, Hughes L, Li L, Armitage J, Arnot J. 2023. Expanding new chemical assessment capacity. Technical Report prepared for Health Canada.

Hughes L, Arnot J. 2023. Expand near-field human exposure and safety estimation capacity in EAS-E Suite including occupational, consumer and general population exposure scenarios.  Technical Report prepared for ACC-LRI.

Brown TN, Li L, Sangion A, Arnot J, 2022. Development of production volume databases for integration into EAS-E Suite. Technical Report prepared for ACC-LRI.

Sangion A, Arnot J. 2022. Addressing uncertainty in toxicokinetics data and applications to advance chemical exposure and risk assessment. Phase 1: Exploratory analysis of toxicokinetics data. Technical Report prepared for ExxonMobil Biomedical Sciences.

Toose L, Sangion A, Armitage J, Li L, Arnot J. 2022. Case study and workshop for guiding the selection of appropriate exposure models for risk assessment using the EAS-E Suite platform. Technical Report prepared for Health Canada.

Sangion A, Armitage J, Arnot J. 2022. Application of mass balance modeling and in vitro and in vivo extrapolation to higher-throughput genetic toxicology assays for risk assessment applications. Technical Report prepared for Health Canada.

Armitage J, Sangion A, Looky A, Arnot JA. 2022. Application of mass balance modeling and in vitro and in vivo extrapolation to support scoping and risk assessment applications for per- and poly-fluorinated alkyl substances (PFAS). Technical Report prepared for Health Canada.

Arnot J, Li L, Toose L, Brown T, Wyatt J. 2022. Fate, exposure, and risk estimation modelling of 4,4'-dichlorodiphenyl sulfone (DCDPS or BCPS; CAS 80-07-9). Technical Report prepared for BASF SE. 

Arnot J, Li L, Toose L, Brown T, Wyatt J. 2022. Addressing uncertainty in the bioaccumulation assessment of 4,4'-dichlorodiphenyl sulfone (DCDPS or BCPS; CAS 80-07-9). Technical Report prepared for BASF SE. 

Brown TN, Li L, Zhang X, Sangion A, Toose L, Wania F, Arnot JA, 2021. Developing guidance and recommendations for using overall fate and monitoring data in a weight-of-evidence for assessing petroleum hydrocarbon persistence under REACH. Technical Report prepared for Concawe.

Arnot JA, Brown TN, Toose L Sangion A, Armitage J. 2021. Modernize Health Canada’s consumer and industrial/aquaculture release models and incorporate them into the EAS-E Suite Platform. Technical Report prepared for Health Canada.

Sangion A, Armitage J, Toose L, Arnot JA. 2021. In vitro and in silico toxicokinetics for high throughput data interpretation: addressing model domain of applicability and uncertainty for in vitro-in vivo extrapolation. Technical Report prepared for Health Canada.

Armitage J, Sangion A, Arnot JA. 2021. Applying in vitro mass balance models to interpret chemical distribution when using in vitro toxicity data for prioritization and assessment activities. Technical Report prepared for Health Canada.

Toose L, Armitage J, Li L, Arnot JA. 2021. Analysis of far-field dietary exposures with food web considerations in human health assessment. Technical Report prepared for Health Canada.

Armitage JM, Hughes L, Li L, Sangion A, Arnot JA. 2020. Comparing a suite of PBTK models to provide preliminary guidance for model selection and application for different possible use-contexts. Technical Report prepared for ACC-LRI.

Toose L, Armitage J, Arnot JA. 2020. Advancing scientific decision making for bioaccumulation and toxicity assessment. progress on revisions to the Bioaccumulation Assessment Tool (BAT). Technical Report prepared for ACC-LRI.

Li L, Arnot JA, Wania F. 2019. Modeling human exposure to chemicals from intermittent applications of consumer products using a steady-state modeling framework. Technical Report prepared for ACC-LRI.

Li L, Arnot JA, Wania F. 2018. Integration of a substance flow model into the RAIDAR framework. Technical Report prepared for ACC-LRI.

Arnot J, Toose L, Armitage J. 2018. Generation of physical-chemical property data and the application of models for estimating fate and transport and exposure and risk potential for organic substances on the Canadian DSL. Technical Report prepared for Environment and Climate Change Canada.

Parmar R, Gouin T, Arnot J. 2018. Compilation of monitoring data from publicly available sources and from data provided by Health Canada. Technical Report prepared for Health Canada.

Givehchi B, Arnot J. 2018. Qualitative and quantitative comparisons of the RAIDAR-ICE model with other exposure models and exposure estimates for select chemicals. Technical Report prepared for Health Canada.

Gouin T, Parmar R, Arnot J. 2018. Recent developments of non-target chemical analysis: Literature review and recommendations for application in human health risk assessment. Technical Report prepared for Health Canada.

Arnot J, Looky A, Foster K, Armitage J. 2018. Development of an in vitro and in vivo biotransformation and toxicokinetic database for fish and rodents. Technical Report for European Commission - Joint Research Centre (JRC).

Armitage JM, Arnot JA. 2017. Application of mass balance modeling to facilitate the interpretation and evaluation of in vitro toxicity data. Technical Report for ACC-LRI.

Arnot J, Armitage J, Escher B, Fischer F, Scholz S, Klüver N, Schmidt S, Mayer P. 2017. Expanding the applicability domain of the chemical activity approach for hazard and risk assessment: Final report for Cefic-LRI ECO.30 project.

National Academies of Sciences Engineering and Medicine. 2017. Using 21st Century Science to Improve Risk-Related Evaluations. Washington, DC: The National Academies Press. DOI

Armitage JM, Arnot JA. 2016. Progress report on a refined Generic PBPK model. Technical Report for ACC-LRI.

Armitage JM, Arnot JA. 2016. TBBPA degradation: Scoping assessment of available data. Technical Report prepared for ICL – Industrial Chemicals. 

Westgate JN, Armitage JM, Arnot JA. 2016. Multimedia modeling of decamethyltetrasiloxane (L4) and dodecamethylpentasiloxane (L5). Technical Report prepared for American Chemistry Council, Silicones Environmental, Health, and Safety Center (SEHSC).

Arnot J, Armitage J, Brown T, Hermens J, Droge S, Jonker M, Chen Y, Mackay D. 2016. Improving the performance and expanding the applicability of a mechanistic bioconcentration model for ionogenic organic compounds (IOCs) in fish (BIONIC): Final Report for Cefic-LRI ECO.21 Project.

Arnot J. 2016. Estimating bioconcentration factors for triclosan using in vitro biotransformation rate data from catfish liver. Technical Report prepared for BASF SE. 

Armitage JM, Arnot JA. 2015. Model development to support monitoring data for assessing the bioaccumulation and biomagnification potential of bifenthrin in terrestrial environments. Technical Report prepared for FMC Chemical.

Arnot J. 2015. A review of the bioaccumulation of triclosan in fish and other species. Technical Report prepared for BASF SE. 

Falls A, Arnot JA. 2015. Applying RAIDAR to address data gaps for assessing the exposure and potential risk of select organic flame retardants to the environment. Technical Report for Environment Canada.

Nichols J, Gobas F, MacLeod M, Borgå K, Leonards P, Papa E, Laue H, Arnot J. 2015. Summary of Cefic-LRI Sponsored Workshop: Recent Scientific Developments in Bioaccumulation Research. Workshop Report prepared for Cefic-LRI. 

Arnot JA. 2014. Bioaccumulation assessment of medium chain chlorinated paraffins (MCCPs). Summary Report prepared for The Regulatory Network Inc.

Armitage JM, Wania F, Arnot JA. 2014. Evaluation of long-range transport (LRT) screening tools and models for pre-market assessment of new pesticides. Technical Report prepared for The Environmental Assessment Directorate, Pest Management Regulatory Agency, Health Canada.

Arnot JA. 2014. Parameterize and apply the Risk Assessment IDentification And Ranking (RAIDAR) model to screen approximately 1370 substances. Technical Report for Environment Canada.

Arnot JA. 2014. Preliminary bioaccumulation assessment of Additiv 104. Technical Draft Report prepared for BP.

Arnot J, Zhang X, Hughes L, Kircanski I. 2014. Develop Sub-Module for Direct Human Exposures to Consumer Products. Technical Report for United States Environmental Protection Agency.

MacLeod M, McLachlan MS, Adolfsson-Erici M, Arnot JA, Borgå K, Mayer P, Nichols J. 2013. Tiered methods for fish trophic magnification factor (TMF²): Final Report for Cefic-LRI ECO.15 Project.

Hermens J, Jonker MTO, van der Heijden S, Mayer P, Gilbert D, Arnot JA, McCarty LS, Mackay D. 2013. Critical body residue validation for aquatic organisms exposed to chemicals causing toxicity by baseline narcosis: Final report for Cefic-LRI ECO.16 project.

Arnot JA. 2013. Comments on preliminary bioaccumulation assessment of medium chain chlorinated paraffins (MCCPs).Technical Report prepared for The Regulatory Network Inc.

Arnot JA, Armitage JM. 2013. Parameterization and application of the RAIDAR model to aid in the prioritization and assessment of chemical substances. Technical Report for Health Canada. 

Arnot JA, Brown, TN. 2013. Developing databases and models for mammalian biotransformation rate and dietary assimilation efficiency for improved bioaccumulation assessment. Technical Report for Environment Canada. 

McLachlan MS, Wania F, Breivik K, Arnot JA, Brown TN. 2012. Development, application, and evaluation of model-based screening procedures for PBT chemicals and POPs: Final report for Cefic-LRI ECO.13 project. 

Arnot JA. 2012. A bioaccumulation hazard assessment of three flame retardant alternatives for DecaBDE. Technical Report prepared for ICL Industrial Products Bromine Compounds Ltd.

Arnot JA, Armitage J, Gilbert N, Wang J. 2012. Developing databases and methods to address uncertainty in microbial chemical biodegradation estimates for ecological and human health assessment. Technical Report for Health Canada.

Arnot JA, Hughes L, Mackay D. 2012. Development of a new Health Canada Far-field Human Exposure (FHX-CAN) model including selected regional Canadian environments. Technical Report for Health Canada.

Arnot JA. 2012. Bioaccumulation test method validation: comparative analysis of trout and carp results from an OECD ring test. Technical Report prepared for United Kingdom Environment Agency and included in OECD Series on Testing and Assessment No. 175 [ENV/JM/MONO(2012)20] “Validation Report of a Ring Test for the OECD 305 Dietary Exposure Bioaccumulation Fish Test (Part 1) with Additional Report including Comparative Analysis of Trout and Carp Results (Part II)”. 

Arnot JA. 2012. Exploring the fate, bioaccumulation and exposure potential of ionogenic chemicals released to the environment using the RAIDAR model. Technical Report for Unilever.

Arnot JA. 2011. Parameterization and application of the RAIDAR model to support prioritization and assessment of substances. Technical Report for Environment Canada.

Arnot JA. 2011. Updating the RAIDAR and FHX models to aid in the prioritization and assessments of chemicals including ionisable substances. Technical Report for Health Canada.

Arnot JA, Armitage JM. 2011. Modelling the bioaccumulation of long chain amines (cationic surfactants) in fish. Technical Report for the APAG Companies.

Arnot JA, Armitage JM. 2011. Modelling the bioconcentration of long chain amines (cationic surfactants) in fish. Technical Report for the APAG Companies.

Arnot JA. 2011. Exploring uncertainty in biotransformation half-lives when modelling the bioaccumulation of bifenthrin in aquatic systems. Technical Report for FMC Corporation.

Arnot JA. 2010. The application of the RAIDAR and FHX models for the rapid exposure-based prioritization of selected organic chemicals. Technical Report for United States Environmental Protection Agency. 

Arnot JA. 2010. Estimating chemical absorption efficiency from dietary exposures and degradation rate constants in the gastro-intestinal tract. Technical Report for Environment Canada. 

Arnot J, Armitage J. 2009. Bioaccumulation and exposure modelling of bifenthrin in aquatic ecosystems. Technical Report for FMC Corporation. 

Arnot J, Armitage J. 2009. Application of mass balance models to interpret bifenthrin bioaccumulation data from an Alabama pond field study. Technical Report for FMC Corporation.

Armitage J, Arnot J. 2009. Evaluative assessment of the bioaccumulation potential of bifenthrin (CAS RN 82657-04-3) in a simplified terrestrial food-chain. Technical Report for FMC Corporation.

Arnot JA, McCarty LS, Armitage J, Toose-Reid L, Wania F, Cousins I. 2009. An evaluation of hexabromocyclododecane (HBCD) for persistent organic pollutant (POP) properties and the potential for adverse effects in the environment. Technical Report for European Brominated Flame Retardant Industry Panel (EBFRIP).

McCarty LS, Arnot JA. 2008. Ecological risk assessment for pyridalyl. Technical Report for Valent USA Corporation.

Arnot JA. 2008. Aquatic exposure estimates for bifenthrin based on four application scenarios. Technical Report for FMC Corporation.

Arnot JA, Mackay D. 2008. Estimation of human intake fractions and total body burdens for selected persistent organic pollutants and petrochemicals. Technical Report for ExxonMobil Biomedical Sciences Inc.

Arnot JA. 2007. A critical review of proposals for molecular size restrictions in bioaccumulation assessments. Technical Report for Environment Canada.

Arnot JA, Mackay D. 2007. Risk prioritization for a subset of Domestic Substances List chemicals using the RAIDAR model. CEMC Report No. 200703. Technical Report for Environment Canada.

Mackay D, Arnot JA, Hickie B, Wania F, Webster E. 2007. Towards a strategy for reviewing substance profiles prepared under Environment Canada’s “Challenge” program. Technical Report for Environment Canada.

Gobas FAPC, Moore MM, Hermens JLM, Arnot JA. 2006. Bioaccumulation reality check. SETAC Globe, Learned Discourse 7(5): 40-41. 

Arnot JA, Mackay D, Webster E. 2006. Health Canada Farfield Model. Technical Report for Health Canada.

Mackay D, Arnot JA. 2006. The toxicity of organic chemicals: does a fugacity perspective help? SETAC Globe, Learned Discourse 7(3): 23-24.

Arnot JA. 2006. Bioconcentration factor and bioaccumulation factor assessments for organic chemicals on the Canadian Domestic Substances List: Database update. Technical Report for Environment Canada.

Arnot JA. 2006. Estimates of metabolic transformation rates in fish. Technical Report for Environment Canada.

Arnot JA, Gouin T, Mackay D. 2005. Practical methods for estimating environmental biodegradation rates. CEMN Report No. 200503. Technical Report for Environment Canada. 

Webster E, Mackay D, Wania F, Arnot JA, Gobas F, Gouin T, Hubbarde J, Bonnell, M. 2005. Development and application of models of chemical fate in Canada: modelling guidance document. CEMN Report No. 200501. Technical Report for Environment Canada.

Arnot JA, Mackay D. 2004. Proceedings of a workshop on the environmental fate of fluorotelomer-based polymers. Canadian Environmental Modelling Network Report No 200401.

Arnot JA. 2004. Recommendations on the bioaccumulation categorization of 502 DSL chemicals. Technical Report for Environment Canada.

Arnot JA. 2004. Compilation and quality assessment of bioconcentration and bioaccumulation factors for 502 chemicals for the DSL categorization. Technical Report for Environment Canada.

Arnot JA. 2004. Recommendations on the bioaccumulation categorization of 502 DSL chemicals. Technical Report for Environment Canada.

Gobas FAPC, Arnot JA. 2004. San Francisco Bay PCB food web model. Technical Report for San Francisco Bay Regional Monitoring Program.

Arnot JA. 2004. Recommendations on the bioaccumulation categorization of 648 DSL chemicals. Technical Report for Environment Canada.

Gobas FAPC, Arnot JA. 2003. The categorization of organic chemicals on the Domestic Substances List for bioaccumulation potential. Technical Report for Environment Canada.

Gobas FAPC, Arnot JA. 2003. Identification of Bioconcentration and Bioaccumulation Factors for 8,000 DSL Substances. Technical Report for Environment Canada.

Gobas FAPC, Arnot JA. 2002. Variability of bioconcentration and bioaccumulation factors with experimental conditions. Technical Report for Environment Canada.

Gobas FAPC, Arnot JA. 2001. Bioaccumulation categorization of organic chemical substances on the DSL. Technical Report for Environment Canada.

Gobas FAPC, Arnot JA. 2000. The application of bioaccumulation models for the categorization and screening of chemical substances on the DSL. Technical Report for Environment Canada.

Gobas FAPC, Arnot JA. 2000. Identification of bioconcentration and bioaccumulation factors for DSL substances. Technical Report for Environment Canada.