ARC Arnot Research & Consulting strives to improve the scientific understanding of the potential hazards and risks chemicals may cause to humans and the environment.

Several thousand chemicals are currently used in society and thousands of new chemicals are developed annually. Globally, legislative programs seek to identify and regulate chemicals that pose hazards and unacceptable risks to humans and the environment. Scientific methods, data, tools and expertise are required to identify chemical hazards and minimize the potential for unacceptable risks to humans and ecosystems.

Our research includes:

-The evaluation of chemicals for potential harmful effects to humans and the environment through hazard (“PBT”), exposure and risk assessment.

– The development, critical evaluation and application of databases, mass balance models and Quantitative Structure-Activity Relationships (QSARs).

We collaborate with colleagues in academia, industry and government.

ARC can provide expert guidance to address scientific uncertainty and save resources in regulated chemical assessments.

September 2024

New open source publication: Brown TN, Armitage JM, Sangion A, Arnot JA. 2024 Improved prediction of PFAS partitioning with PPLFERs and QSPRs. Environ. Sci.: Process. Impacts, Accepted September 21, DOI: 10.1039/d4em00485j.

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EAS-E Suite (BETA) Ver.0.97.

Available Now: EAS-E Suite (BETA) Ver.0.97. Register below for access.

Released June 2023

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IV-MBM Ver.2.0

November 2021

New open source publication: “Update and Evaluation of a High-Throughput In Vitro Mass Balance Distribution Model: IV-MBM EQP v2.0.” by Armitage et al.

The New IV-MBM Ver.2.0 is available in EAS-E Suite.

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BAT Ver.2.0

Ver. 2.0 Released May 2021

Ver. 2.02 Released Sept. 2021

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BAT Ver. 2.03

COMING SOON FALL 2024!

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RAIDAR-ICE Ver.1.52

Released May 2021

 

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PROTEX-HT

January 2022

New open source publication: “Development and Evaluation of a Holistic and Mechanistic Modeling Framework for Chemical Emissions, Fate, Exposure, and Risk.” by Li et al. in Environmental Health Perspectives.

 The new model described and evaluated in this publication consolidates various databases and models to simulate chemical emissions, environmental fate in indoor and natural environments, food web bioaccumulation, aggregate exposure to humans and ecological receptors, and risk estimates at a screening-level requiring only chemical structure and production volume information as input parameters.

Click below to register and try PROTEX-HT for free in EAS-E Suite.

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open source publication May 2021

Development and intercomparison of single and multicompartment physiologically-based toxicokinetic models:

Implications for model selection and tiered modeling frameworks” by Armitage et al. in Environment International

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February 17, 2021

ARC research highlighted at the ACC LRI

“Improving understanding of indoor exposures”

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January 2021

New open source publication:

“Addressing uncertainty in mouthing-mediated ingestion of chemicals on indoor surfaces, objects, and dust”, by Li et al.

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