Jon Arnot, PhD

Dr. Jon Arnot founded ARC Arnot Research & Consulting in January 2010 after several years of part-time research and consulting as a sole proprietor during his graduate studies and postdoctoral appointment. Jon completed a two year Natural Sciences and Engineering Research Council (NSERC) of Canada postdoctoral fellowship under the supervision of Professor Frank Wania at the University of Toronto Scarborough. His PhD at Trent University was completed in 2008 under the supervision of Professor Emeritus Don Mackay and his Masters of Environmental Toxicology at Simon Fraser University was supervised by Professor Frank Gobas.

Over the past 10 years his research has included the development, application and evaluation of methods and models for assessing the exposure, hazard and risk of organic chemicals to humans and the environment including the AQUAWEB, RAIDAR, FHX, and FHX-CAN mass balance models.

In collaboration with the U.S. EPA, Environment Canada and Syracuse Research Corporation he developed a QSAR to estimate primary biotransformation rates for fish from chemical structure. Jon has co-developed models that are used for regulatory purposes in Canada, the U.S. and Europe
(e.g., models included in U.S. EPA’s EPI Suite™ and the OECD Toolbox).

Jon is actively involved in research developing methods and tools to help better understand chemical hazard, exposure and risk for applications in various regulatory programs.

jon@arnotresearch.com


Refereed Publications - Jon Arnot, PhD

Costanza J, Boethling RS, Lynch DG, Arnot JA. 2012. Use of the bioaccumulation factor to screen chemicals for bioaccumulation potential. In press Environ Toxicol Chem DOI 10.1002/etc.1944

Brown TN, Arnot JA, Wania F. 2012. Iterative fragment selection: A group contribution approach to predicting fish biotransformation half-lives. Environ Sci Technol DOI 10.1021/es301182a

Breivik K, Arnot JA, Brown TN, McLachlan MS, Wania F. 2012. Screening organic chemicals in commerce for emissions in the context of environmental and human exposure. J Environ Monit 14:2028 - 2037

Gama SR, Mackay D, Arnot JA. 2012. Selecting and designing chemicals: application of a mass balance model of chemical fate, exposure and effects in the environment. Green Chem 14:1094-1102.

Burkhard L, Arnot JA, Embry M, Farley K, Hoke R, Kitano M, Leslie HA, Lotufo GR, Parkerton TF, Sappington KG, Tomy GT, Woodburn K. 2012. Comparing laboratory and field measured biota-sediment accumulation factors. Integrated Environmental Assessment and Management 8(1): 32-41.

Burkhard L, Arnot JA, Embry M, Farley K, Hoke R, Kitano M, Leslie HA, Lotufo GR, Parkerton TF, Sappington KG, Tomy GT, Woodburn K. 2012. Comparing laboratory and field measured bioaccumulation endpoints. Integrated Environmental Assessment and Management 8(1): 17-31.

Marvin CH, Tomy GT, Armitage JM, Arnot JA, McCarty LS, Covaci A, Palace V. 2011. Hexabromocyclododecane: current understanding of chemistry, environmental fate and toxicology and implications for global management. Environ Sci Technol 45(20): 8613-8623.

Sverko E, Tomy GT, Reiner EJ, Li Y-F, McCarry BE, Arnot JA, Law RJ, Hites RA. 2011. Dechlorane Plus and related compounds in the environment: a review. Environ Sci Technol 45(12): 5088-5098.

Mackay D, Arnot JA. 2011. The application of fugacity and activity to simulating the environmental fate of organic contaminants. J Chem Eng Data 56(4): 1348-1355.

Mackay D, Arnot JA, Wania F, Bailey RE. 2011. Chemical activity as an integrating concept in environmental assessment and management of contaminants. Integrated Environmental Assessment and Management 7(2): 248-255.

Arnot JA, Armitage JM, McCarty LS, Wania F, Cousins I, Toose-Reid L. 2011. Toward a consistent evaluative framework for POP risk characterization. Environ Sci Technol 45(1): 97-103. Special Issue on Environmental Policy: Past, Present and Future – Invited

McLachlan MS, Czub G, MacLeod M, Arnot JA. 2011. Bioaccumulation of organic contaminants in humans: A multimedia perspective and the importance of biotransformation. Environ Sci Technol 45(1): 197-202. Special Issue on Environmental Policy: Past, Present and Future

Arnot JA, Mackay D, Sutcliffe R, Lo B. 2010. Estimating farfield organic chemical exposures, intake rates and intake fractions to human age classes. Environ Modell Softw 25:1166-1175.

Gobas FAPC, Arnot JA. 2010. Food web bioaccumulation model for polychlorinated biphenyls in San Francisco Bay, California, USA. Environ Toxicol Chem 29:1385-1395.

Arnot JA, Arnot MI, Mackay D, Couillard Y, MacDonald D, Bonnell M, Doyle P. 2010. Molecular size cut-off criteria for assessing bioaccumulation potential: Fact or fiction? Integrated Environmental Assessment and Management 6(2): 210-224.

Arnot JA, Mackay D, Parkerton TF, Zaleski RT, Warren CS. 2010. Multimedia modelling of human exposure to chemical substances: the roles of biomagnification and biotransformation. Environ Toxicol Chem 29(1): 45-55.

-Cowan-Ellsberry C, McLachlan M, Arnot JA, MacLeod MJ, McKone TE, Wania F. 2009. Modeling exposure to persistent chemicals in hazard and risk assessment. Integrated Environmental Assessment and Management 5(4): 662-679.

Mackay D, Arnot JA, Petkova EP, Wallace KB, Call DJ, Brooke LT, Veith GD. 2009. The physicochemical basis of QSARs for baseline toxicity. SAR and QSAR in Environmental Research 20: 393-414.

Warren CS, Mackay D, Webster E, Arnot JA. 2009. A cautionary note on implications of the well-mixed compartment assumption as applied to mass balance models of chemical fate in flowing systems. Environ Toxicol Chem 28(9): 1858-1865.

Arnot JA, Meylan W, Tunkel J, Howard PH, Mackay D, Bonnell M, Boethling RS. 2009. A quantitative structure-activity relationship for predicting metabolic biotransformation rates for organic chemicals in fish. Environ Toxicol Chem 28(6): 1168-1177.

SETAC Best Student Paper Award Powell A, Mackay D, Webster E, Arnot JA. 2009. Modelling bioaccumulation using characteristic times. Environ Toxicol Chem 28(2): 272-278.

Arnot JA, Mackay D, Parkerton TF, Bonnell M. 2008. A database of fish biotransformation rates for organic chemicals. Environ Toxicol Chem 27(11): 2263-2270.

Arnot JA, Mackay D. 2008. Policies for chemical hazard and risk priority setting: Can persistence, bioaccumulation, toxicity and quantity information be combined? Environ Sci Technol 42: 4648-4654.

Arnot JA, Mackay D, Bonnell M. 2008. Estimating metabolic biotransformation rates in fish from laboratory data. Environ Toxicol Chem 27(2): 341-351.

Parkerton TF, Arnot JA, Weisbrod AV, Russom C, Hoke RA, Woodburn K, Traas T, Bonnell M, Burkhard LP and Lampi, MA. 2008. Guidance for evaluating in-vivo fish bioaccumulation data. Integrated Environmental Assessment and Management 4(2): 139-155.

Weisbrod AV, Burkhard LP, Arnot JA, Mekenyan O, Howard PH, Russom C, Boethling R, Sakuratani Y, Traas T, Bridges T, Lutz C, Bonnell M, Woodburn K. 2007. Workgroup report: review of fish bioaccumulation databases used to identify persistent, bioaccumulative, toxic substances. Environ Health Persp 115(2): 255-261.

Arnot JA, Mackay D, Webster E, Southwood J. 2006. Screening level risk assessment model for chemical fate and effects in the environment. Environ Sci Technol 40: 2316-2323.

Arnot JA, Gobas FAPC. 2006. A review of bioconcentration factor (BCF) and bioaccumulation factor (BAF) assessments for organic chemicals in aquatic organisms. Environ Rev 14: 257-297.

Arnot JA, Gobas FAPC. 2004. A food web bioaccumulation model for organic chemicals in aquatic ecosystems. Environ Toxicol Chem 23(10): 2343–2355.

Arnot JA, Gobas FAPC. 2003. A generic QSAR for assessing the bioaccumulation potential of organic chemicals in aquatic food webs. QSAR Comb Sci 22(3): 337-345.

Gobas FAPC, Kelly BC, Arnot JA. 2003. Quantitative structure-activity relationships for predicting the bioaccumulation of POPs in terrestrial food webs. QSAR Comb Sci 22(3): 329-336.

Chapters in Books

Arnot JA, Mackay D. Fugacity and bioaccumulation. 2010. Vignette in Fundamentals of Ecotoxicology, Third Edition, Newman MC, Ed. CRC Press pp. 101-106.

Mackay D, Arnot JA, Webster E, Reid L. 2009. The evolution and future of environmental fugacity models. Chapter in Ecotoxicology Modeling. Devillers J, Ed. Springer pp. 355-375.

Arnot JA. 2009. Mass balance models for chemical fate, bioaccumulation, exposure and risk assessment. Chapter in Exposure and Risk Assessment of Chemical Pollution – Contemporary Methodology. NATO Science for Peace and Security Series C: Environmental Security. Simeonov L and Hassanien M, Eds. Springer pp. 69-91.

Arnot JA. 2009. Exposure and risk assessment modelling to screen and prioritize commercial chemical inventories. Chapter in Exposure and Risk Assessment of Chemical Pollution – Contemporary Methodology. NATO Science for Peace and Security Series C: Environmental Security. Simeonov L and Hassanien M, Eds. Springer pp. 93-109.